1. Ex Vivo Assessment of Neointimal Characteristics After Drug-eluting Stent Implantation: Optical Coherence Tomography and Histopathology Validation Study

    Ex Vivo Assessment of Neointimal Characteristics After Drug-eluting Stent Implantation: Optical Coherence Tomography and Histopathology Validation Study

    Background Optical coherence tomography (OCT) is one of the tools trying to distinguish neoatherosclerosis from other neointimal tissue but its role has to be still validated. This study evaluated the diagnostic accuracy of OCT for characterization of lipid-atherosclerotic neointima following drug-eluting stent (DES) implantation. Methods Twelve stented coronary arteries from the 7 autopsy hearts were imaged by OCT. These OCT images were compared with histology. By OCT, the morphological appearances of neointima were classified into three patterns: homogeneous pattern, heterogeneous pattern with visible strut, or heterogeneous pattern with invisible strut. Results Of 21 histological cross-sections, 6 were categorized as homogeneous ...

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