1. Aqueous outflow regulation: Optical coherence tomography (OCT) imaging implicates pressure-dependent tissue motion

    Aqueous outflow regulation: Optical coherence tomography (OCT) imaging implicates pressure-dependent tissue motion

    Glaucoma is a leading cause of blindness worldwide and results from damage to the optic nerve. Currently, intraocular pressure is the only treatable risk factor. Changes in aqueous outflow regulate pressure; regulation becomes abnormal in glaucoma. From inside the eye aqueous flows out through the trabecular meshwork into a venous sinus called Schlemm's canal, next into collector channels and finally returns to the episcleral vessels of the venous system. The location of aqueous outflow regulation is unknown. Ex vivo and in vivo studies implicate both pressure-dependent trabecular tissue motion and tissues distal to Schlemm's canal in regulation of ...

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