PhD Position at University of Strasbourg in Optical coherence tomography (OCT) for guidance of robotized interventional endoscopy
The thesis is focused on combining two unique technologies: an optical diagnostic method using optical coherence tomography (OCT) and robotized flexible endoscopy to answer a clinical need for early detection and planning of minimally invasive treatment of early stage cancer. This research project will be conducted at the ICube Laboratory (a joint Strasbourg University/CNRS research unit) and will be focused on addressing scientific and engineering challenges related to robotically assisted wide-field microscopic medical imaging. The new endoscopic OCT method developed will be integrated with an existing prototype of robotized interventional endoscope and tested in bench-top experiments and in vivo animal studies in partnership with clinical collaborators. As such, this is a highly interdisciplinary project with a broad biomedical engineering profile that includes aspects of medical imaging, robotics, mechatronics, system control and photonics.
The main goal of this thesis proposal is to address clinical needs of minimally invasive treatment of early cancer in luminal organs (e.g. intestine). Such treatment requires complex operation of the endoscope and resection instruments in a confined space of the colon lumen. A promising solution is being developed by the AVR team at the ICube laboratory, in which the flexible interventional endoscope is completely robotized, so allowing a single operator to telemanipulate the device. However, this solution is subject to the same diagnostic limitations of standard endoscopy that impairs the clinical decision-making process. In this thesis we propose to address this problem by combining optical coherence tomography (OCT), an emerging optical diagnostic tool, with the robotized interventional endoscope prototype to enhance its diagnostic capabilities and provide real-time and in-situ tissue characterization. The OCT imaging system design and integration of both devices will be optimized and validated in pre-clinical experiments (including in vivo animal studies) in partnership with clinical collaborators.
This thesis will be conducted at the ICube Laboratory, a joint Strasbourg University/CNRS research unit. This highly interdisciplinary project will be directed in a collaborative manner between the Photonics Instrumentation and Processes team (IPP) led by Dr. Paul Montgomery, director of the thesis, who has over 20 years of experience in interference microscopy, and the Control, Vision and Robotics (AVR) team (Prof. Michel de Mathelin, thesis co-director) specializing in robotized interventional endoscopes. Dr. Michalina Gora (AVR/IPP) will be directly involved in supervising and providing the necessary guidance, especially in the endoscopic OCT. The student will have an opportunity to participate in short-term internships in the laboratory of Prof. Guillermo Tearney at Harvard Medical School and Massachusetts General Hospital in Boston, USA.
The applicants are expected to have a master's degree from a foreign university or to have enrolled in a MASTER program at the University of Strasbourg in order to register in doctoral studies, after completion of a complete bachelor’s degree course in a university abroad in biomedical engineering, optical engineering, automatic control and robotics, electrical and computer engineering, or applied physics, and demonstrated excellence in at least one of the following areas: optical systems, medical imaging, mechatronics, visual servoing, control application programing (e.g. LabVIEW), image/signal processing (e.g. MATLAB), and CAD (e.g. Solid Edge).
Moreover the candidate shall have additional skills as: • strong communication skills in English, both written and spoken, • enthusiasm for interdisciplinary teamwork, • aptitude for practical experimentation, • abilities of working independently, setting priorities and meeting deadlines. Nr of positions available : 1
Engineering - Other
Early stage researcher or 0-4 yrs (Post graduate)
First Stage Researcher (R1) Comment/web site for additional job details Envisaged job starting date : 01/10/2016 Application deadline : 30/09/2019 Application e-mail : firstname.lastname@example.org www.unistra.fr/index.php?id=16468