1. Non-invasive Imaging of Localised Scleroderma for Assessment of Skin Blood Flow and Structure

    Non-invasive Imaging of Localised Scleroderma for Assessment of Skin Blood Flow and Structure

    xtensive morphoea causes major morbidity, disability and disfigurement; pathophysiology is poorly understood. The aim of this study was to investigate, with non-invasive imaging, the relationship between localised abnormalities of skin structure and perfusion, which characterise morphoea. Thirty-two patients with mor­phoea underwent imaging at affected and unaffected sites. Skin thickness was imaged with optical coherence tomography (OCT) and high-frequency ultrasound (HFUS). Perfusion was imaged with dual-wavelength laser Doppler imaging (LDI) and thermography. Epidermal thickness showed a small increase from affected to unaffected site (OCT, active and inactive plaques [ p = 0.005 and p = 0.004], HFUS active plaques only [ p ...

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