1. Enhanced Adventitial Vasa Vasorum Formation in Patients With Vasospastic Angina Assessment With OFDI

    Enhanced Adventitial Vasa Vasorum Formation in Patients With Vasospastic Angina Assessment With OFDI

    Coronary artery spasm plays important roles in the pathogenesis of a wide range of ischemic heart disease. Recent studies have demonstrated that coronary spasm is frequently noted in Caucasians as in Asians (1) . We previously demonstrated that vascular smooth muscle cell hypercontraction through Rho-kinase activation is the key mechanism of the spasm, for which adventitial inflammatory changes may be involved (1) . The adventitia has recently attracted much attention as a source of inflammation as it harbors nutrient blood vessels called vasa vasorum (VV). Indeed, VV plays an important role as a supply route of vascular inflammation in the progression of ...

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