Enhanced Adventitial Vasa Vasorum Formation in Patients With Vasospastic Angina Assessment With OFDI
Coronary artery spasm plays important roles in the pathogenesis of a wide range of ischemic heart disease. Recent studies have demonstrated that coronary spasm is frequently noted in Caucasians as in Asians (1) . We previously demonstrated that vascular smooth muscle cell hypercontraction through Rho-kinase activation is the key mechanism of the spasm, for which adventitial inflammatory changes may be involved (1) . The adventitia has recently attracted much attention as a source of inflammation as it harbors nutrient blood vessels called vasa vasorum (VV). Indeed, VV plays an important role as a supply route of vascular inflammation in the progression of ...
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