1. Quantitative assessment of oral microstructural and microvascular changes in late oral radiation toxicity, using noninvasive in-vivo optical coherence tomography

    Quantitative assessment of oral microstructural and microvascular changes in late oral radiation toxicity, using noninvasive in-vivo optical coherence tomography

    Background and objectives: About half of the head and neck cancer patients treated with radiotherapy suffer from late radiation effects months to years after the treatment. The most common diagnosis and monitoring methods for such oral toxicities are based on surface examination of the oral tissue, which is subjective. Therefore, subsurface imaging and image quantification tools can be highly useful for monitoring these late effects as these approaches are more robust and objective. In this study, we demonstrate the ability of optical coherence tomography (OCT) technology and its newly developed quantitative imaging platform to reveal subsurface microstructural and microvascular changes ...

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