1. Sex Differences in Airway Remodeling in a Mouse Model of Chronic Obstructive Pulmonary Disease

    Sex Differences in Airway Remodeling in a Mouse Model of Chronic Obstructive Pulmonary Disease

    Rationale: Adjusting for the amount of smoking, women have a 50% increased risk of COPD compared with men. It is not known what the anatomic basis/mechanism(s) of these sex-related differences in COPD might be. Objective: To characterize the impact of female sex hormones on chronic cigarette smoke-induced airway remodeling and emphysema in a mouse model of COPD. Methods: Airway remodeling and emphysema were determined morphometrically in male, female, and ovariectomized mice exposed to 6 months of cigarette smoke. Antioxidant- and transforming growth factor (TGFβ)-related genes were profiled in airway tissues. The selective estrogen receptor modulator, tamoxifen, was ...

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