1. Biofunctionalization of Large Gold Nanorods Realizes Ultrahigh-Sensitivity Optical Imaging Agents

    Biofunctionalization of Large Gold Nanorods Realizes Ultrahigh-Sensitivity Optical Imaging Agents

    Gold nanorods (GNRs, ~50 x 15 nm) have been used ubiquitously in biomedicine for their optical properties, and many biofunctionalization methods have been described for them. Recently, the synthesis of larger-than-usual GNRs (LGNRs, ~100 x 30 nm) has been demonstrated. However, LGNRs have not been biofunctionalized and therefore remain absent from biomedical literature to date. Here we report the first biofunctionalization of LGNRs, resulting in highly stable particles with a narrow spectral peak (FWHM ~100 nm). We further demonstrated that functionalized LGNRs can be used as highly sensitive contrast agents for Optical Coherence Tomography (OCT), visualizing individual LGNRs in clear ...

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