1. Optical Coherence Tomography and Virtual-Histology Intravascular Ultrasound Strange Bedfellows? … or Not?

    Optical Coherence Tomography and Virtual-Histology Intravascular Ultrasound Strange Bedfellows? … or Not?

    The ultimate goal of studies such as the one by Brown et al 1 in this issue of Circulation: Cardiovascular Imaging is to provide the clinician with a diagnostic tool that identifies high-risk plaques prospectively to treat and prevent acute events. This tool must have a high positive predictive value and negative predictive value in the clinical setting and not require specific expertise or core-laboratory analysis to determine whether a plaque is vulnerable and should be treated pre-emptively—a yes/no, treat/don’t treat tool. Optical coherence tomography (OCT) has been proposed as that tool. OCT criteria for a ...

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