Optical Technique Provides Improved 'Virtual Biopsies' Of Internal Surfaces

A new optical imaging technique, developed at the Wellman Center for Photomedicine at Massachusetts General Hospital (MGH), can provide three-dimensional microscopic views of the inner surfaces of blood vessels and gastrointestinal organs. In their report in the journal Nature Medicine, receiving early online release today, the MGH-Wellman researchers describe using optical frequency-domain imaging (OFDI) to visualize broad areas of the esophagus and coronary arteries of living pigs. The technique is an advance over optical coherence tomography (OCT) -- another noninvasive MGH-developed technology that details much smaller areas -- and could be useful for identifying precancerous lesions and dangerous deposits of plaque ...
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