1. Optical Technique Provides Improved 'Virtual Biopsies' Of Internal Surfaces

    Optical Technique Provides Improved 'Virtual Biopsies' Of Internal Surfaces
    A new optical imaging technique, developed at the Wellman Center for Photomedicine at Massachusetts General Hospital (MGH), can provide three-dimensional microscopic views of the inner surfaces of blood vessels and gastrointestinal organs. In their report in the journal Nature Medicine, receiving early online release today, the MGH-Wellman researchers describe using optical frequency-domain imaging (OFDI) to visualize broad areas of the esophagus and coronary arteries of living pigs. The technique is an advance over optical coherence tomography (OCT) -- another noninvasive MGH-developed technology that details much smaller areas -- and could be useful for identifying precancerous lesions and dangerous deposits of plaque ...
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    1. For diagnosing early-stage disease, the clinician has been basically looking for a needle in a haystack; so sampling only a few microscopic points of an organ, as we could with OCT, is clearly not sufficient.
    2. One of the most exciting concepts would be to directly link OFDI with the delivery of therapy, such as laser treatment for early cancer.
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