1. In-Stent Restenosis Caused by a Calcified Nodule: A Novel Pattern of Neoatherosclerosis

    In-Stent Restenosis Caused by a Calcified Nodule: A Novel Pattern of Neoatherosclerosis

    Neoatherosclerosis has been described as a cause of in-stent restenosis particularly in patients treated with drug-eluting stents. Although neoatherosclerosis may present as calcified plaques the occurrence of a “calcified nodule” within the stent has not been previously reported. We describe optical coherence tomography findings in patient presenting with a calcified nodule causing “undilatable” in-stent restenosis 2 years after implantation of a drug-eluting stent. The clinical and technical implications of this novel pattern of neoatherosclerosis are discussed.

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