1. Plaque Microstructures in Patients with Coronary Artery Disease who Achieved Very Low Low-Density Lipoprotein Cholesterol Levels

    Plaque Microstructures in Patients with Coronary Artery Disease who Achieved Very Low Low-Density Lipoprotein Cholesterol Levels

    Objective Lowering low-density lipoprotein cholesterol (LDL-C) with statins reduces cardiovascular events and slows plaque progression. While this therapeutic approach has been reported to favourably modify plaque composition, this is not well characterized in humans. Also, the benefit of achieving LDL-C levels below current recommended targets remains unknown. Frequency-domain optical coherence tomography (FD-OCT) enables visualization of plaque microstructures associated with plaque instability. We investigated plaque morphologies in patients with low LDL-C levels by using FD-OCT. Methods 293 and 122 non-obstructive lipid and fibrous plaques in 280 stable statin-treated CAD patients were evaluated by FD-OCT imaging in vessels requiring percutaneous coronary intervention ...

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