1. Characterizing the Impact of Off-Axis Scan Acquisition on the Reproducibility of Total Retinal Thickness Measurements in SDOCT Volumes

    Characterizing the Impact of Off-Axis Scan Acquisition on the Reproducibility of Total Retinal Thickness Measurements in SDOCT Volumes

    Purpose : Off-axis acquisition of spectral domain optical coherence tomography (SDOCT) images has been shown to increase total retinal thickness (TRT) measurements. We analyzed the reproducibility of TRT measurements obtained using either the retinal pigment epithelium (RPE) or Bruch's membrane as reference surfaces in off-axis scans intentionally acquired through multiple pupil positions. Methods : Five volumetric SDOCT scans of the macula were obtained from one eye of 25 normal subjects. One scan was acquired through a central pupil position, while subsequent scans were acquired through four peripheral pupil positions. The internal limiting membrane, the RPE, and Bruch's membrane were segmented ...

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