1. Illuminating Culprit Plaque Histology by Optical Coherence Tomography : Shedding New Light on Old Insights

    Illuminating Culprit Plaque Histology by Optical Coherence Tomography : Shedding New Light on Old Insights

    Coronary atherosclerosis continues to be major cause of death in the developed world ( (1) ). Although we have known for at least a century that fissures and ruptures of coronary arteries are the cause of coronary thrombosis and, in the last 2 decades, that plaque erosion and calcified nodule are additional causes of thrombosis, our ability to use this knowledge in a real-time fashion to affect the treatment of patients with acute coronary syndromes (ACS) has been limited ( (2) ). Although angiography-guided percutaneous coronary intervention (PCI) has become the standard of care for treatment of ACS, it provides little understanding of culprit ...

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