1. Optical coherence tomography for cross-sectional imaging of neural activity

    Optical coherence tomography for cross-sectional imaging of neural activity

    Abstract. We report a functional optical coherence tomography cross-sectional scanner to detect neural activity using unmyelinated nerves dissected from squid. The nerves, unstained or stained with a voltage-sensitive dye, were imaged in a nerve chamber. Transient phase changes from backscattered light were detected during action potential propagation. The results show that the scanner can provide high spatiotemporal resolution cross-sectional images of neural activity ( 15     μ s / A - line ; 0.25     ms / B - scan ; ∼ 8.5 × 5.5     μ m 2 in x z ). The advantage of this method compared to monitoring a single depth profile z is a dramatic increase in the ...

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