1. Cholesterol crystals identified using optical coherence tomography and virtual histology intravascular ultrasound

    Cholesterol crystals identified using optical coherence tomography and virtual histology intravascular ultrasound

    The deposition and accumulation of lipid within the arterial wall leads to the development and progression of atherosclerotic plaques. Cholesterol crystals (CCs) are formed from these lipid pools and both augment the inflammatory response and promote plaque rupture, possibly through inducing mechanical instability. Accordingly, identification of these structures is important for plaque risk stratification. Optical coherence tomography (OCT) and virtual histology intravascular ultrasound (VH-IVUS) are invasive imaging modalities that permit plaque characterisation. Validation studies using these techniques have demonstrated their reliability to identify plaque constituents, including lipid and calcification. CCs are thought to be identifiable on OCT as linear, high-backscattering ...

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