1. Quantifying pharmaceutical film coating with optical coherence tomography and terahertz pulsed imaging: an evaluation

    Quantifying pharmaceutical film coating with optical coherence tomography and terahertz pulsed imaging: an evaluation

    Spectral domain optical coherence tomography (SD-OCT) has recently attracted a lot of interest in the pharmaceutical industry as a fast and non-destructive modality for quantification of thin film coatings that cannot easily be resolved with other techniques. Due to the relative infancy of this technique, much of the research to date has focused on developing the in-line measurement technique for assessing film coating thickness. To better assess OCT for pharmaceutical coating quantification, this paper evaluates tablets with a range of film coating thickness measured using OCT and terahertz pulsed imaging (TPI) in an off-line setting. In order to facilitate automated ...

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