1. Optical coherence tomography in multiple sclerosis; Thickness of the retinal nerve fiber layer as a potential measure of axonal loss and brain atrophy

    Background Axonal distribution within the retinal nerve fiber layer (RNFL) measured by optical coherence tomography (OCT) correlates with axonal viability and integrity. Objective To investigate correlations between RNFL and MRI measures of axonal loss in MS patients. Methods Fifty one remitting-relapsing MS patients, 20 with a history of optic neuritis (MS-ON), 31 without optic neuritis (MS N-ON), and 12 healthy control subjects (HC) were included in the study. RNFL was measured by OCT and brain atrophy was assessed by MRI. Results The average RNFL in the affected eye (AE) in the MS-ON group was significantly lower than the RNFL in ...
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