1. Depth-Resolved Dynamics of Aceto-Whitening in Rabbit Cornea Studied by 1300 nm Optical Coherence Tomography

    Depth-Resolved Dynamics of Aceto-Whitening in Rabbit Cornea Studied by 1300 nm Optical Coherence Tomography

    In many developing parts of the world, colposcopy supplemented by aceto-whitening remains the most widespread means of reliably diagnosing cervical dysplasia, potentially leading to cervical cancer. The use of aceto-whitening to enhance detection rates for Barrett’s esophagus is also emerging in recent years. Here we quantitatively study the aceto-whitening phenomenon using 1300 nm optical coherence tomography. By exposing a simple epithelial tissue model (excised rabbit cornea) to 0.5 M acetic acid we report for the first time to our knowledge the direct measurement of the time over which the cellular brightening effect propagates down through the epithelial layer ...

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