1. The Project MACULA retinal pigment epithelium grading system for histology and optical coherence tomography in age-related macular degeneration

    The Project MACULA retinal pigment epithelium grading system for histology and optical coherence tomography in age-related macular degeneration

    Purpose: To seek pathways of retinal pigment epithelium (RPE) fate in age-related macular degeneration via a morphology grading system ; provide nomenclature, visualization targets, and metrics for cl in ical imag in g and model system s. Methods: Donor eyes with geographic atrophy (GA) or choroidal neovascularization (CNV) and one GA eye with previous cl in ical spectral doma in optical coherence tomography (SDOCT) imag in g were processed for histology , photodocumented, and annotated at pre-def in ed locations. RPE cells conta in ed sp in dle-shaped melanosomes, apposed a basal lam in a or basal lam in ar deposit (BLamD ...

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