1. Cardiac-Gated En Face Doppler Measurement of Retinal Blood Flow Using Swept Source Optical Coherence Tomography at 100,000 Axial Scans per Second

    Cardiac-Gated En Face Doppler Measurement of Retinal Blood Flow Using Swept Source Optical Coherence Tomography at 100,000 Axial Scans per Second

    Purpose: To develop and demonstrate a cardiac gating method for repeatable in vivo measurement of total retinal blood flow (TRBF) in humans using en face Doppler optical coherence tomography (OCT) at commercially available imaging speeds. Methods: A prototype swept-source OCT system operating at 100 kHz axial scan rate was developed and interfaced with a pulse oximeter. Using the plethysmogram measured from the earlobe, Doppler OCT imaging of a 1.5 mm×2 mm area at the optic disc at 1.8 volumes/sec was synchronized to cardiac cycle to improve sampling of pulsatile blood flow. Post-processing algorithms were developed to ...

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