1. En face optical coherence tomography of foveal microstructure in full-thickness macular hole: a model to study perifoveal Müller cells

    En face optical coherence tomography of foveal microstructure in full-thickness macular hole: a model to study perifoveal Müller cells

    Purpose To characterize perifoveal intraretinal cavities observed around full-thickness macular holes (MH) using en face optical coherence tomography and to establish correlations with histology of human and primate maculae. Design Retrospective non-consecutive observational case series. Methods Macular en face scans of eight patients with MH were analyzed to quantify the areas of hyporeflective spaces, and compared with macular flat-mounts and sections from one normal human donor eye and two normal primate eyes (Macaca fascicularis). Immunohistochemistry was used to study the distribution of glutamine synthetase, expressed by Müller cells, and zonula occludens-1, a tight-junction protein. Results The mean area of ...

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