1. Optical coherence tomography visualizes neurons in human entorhinal cortex

    Optical coherence tomography visualizes neurons in human entorhinal cortex

    The cytoarchitecture of the human brain is of great interest in diverse fields: neuroanatomy, neurology, neuroscience, and neuropathology. Traditional histology is a method that has been historically used to assess cell and fiber content in the ex vivo human brain. However, this technique suffers from significant distortions. We used a previously demonstrated optical coherence microscopy technique to image individual neurons in several square millimeters of en-face tissue blocks from layer II of the human entorhinal cortex, over 50     μ m in depth. The same slices were then sectioned and stained for Nissl substance. We registered the optical coherence tomography (OCT) images ...

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