1. Assessing age-related changes in the biomechanical properties of rabbit lens using a co-aligned ultrasound and optical coherence elastography system

    Assessing age-related changes in the biomechanical properties of rabbit lens using a co-aligned ultrasound and optical coherence elastography system

    Purpose: To evaluate the capability of a novel co-aligned focused ultrasound and phase-sensitive optical coherence elastography (US-OCE) system to assess age-related changes in biomechanical properties of the crystalline lens in situ. Methods: Low-amplitude elastic deformations in young and mature rabbit lenses were measured by the US-OCE system consisting of a spectral-domain optical coherence tomography (OCT) system co-aligned with focused ultrasound used to produce a transient force on the lens surface. Uniaxial compressional tests were used to confirm the OCE data. Results: The OCE measurements showed that the maximum displacements of the young rabbit lenses were significantly larger than those of ...

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