1. In Search of the Vulnerable Plaque Is There Any Light at the End of the Catheter?

    In Search of the Vulnerable Plaque Is There Any Light at the End of the Catheter?

    Plaque destabilization with consequent rupture (or erosion) and superimposed thrombosis is the proximate cause of acute coronary syndromes (ACS). Although ACS treatment has advanced considerably in the past decade, the ability to detect, predict, and prevent plaque vulnerability remains elusive. Several imaging tools have been developed to characterize morphological determinants of plaque vulnerability 1 . Among these, intravascular ultrasound (IVUS) is useful for characterizing stenosis severity, plaque burden (PB), remodeling, and calcification but has low resolution and limited ability to detect plaque erosion, rupture, and thrombus. Optical coherence tomography (OCT) can characterize plaques but possesses poor penetration, thereby limiting assessment of ...

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