1. High-Speed Ultrahigh-Resolution OCT of Bruch's Membrane in Membranoproliferative Glomerulonephritis Type 2

    High-Speed Ultrahigh-Resolution OCT of Bruch's Membrane in Membranoproliferative Glomerulonephritis Type 2

    Membranoproliferative glomerulonephritis (MPGN) type 2 is characterized by electron-dense deposits in the glomerular basement membrane and drusen-like deposits in Bruch's membrane. Over time, atrophic changes in the retina and retinal pigment epithelium occur, which can progress to choroidal neovascularization (CNV). This report describes a patient with MPGN type 2 who developed progressive loss of vision secondary to CNV. High-speed ultrahigh-resolution optical coherence tomography (UHR-OCT) showed an irregular Bruch's membrane that measured 10 μm beneath the foveal center. High-speed UHR-OCT can potentially be used to analyze Bruch's membrane in secondary ocular manifestations of diseases such as MPGN type ...

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