1. Baseline OCT Measurements in the Idiopathic Intracranial Hypertension Treatment Trial: Part I. Quality Control,Comparisons and Variability

    Baseline OCT Measurements in the Idiopathic Intracranial Hypertension Treatment Trial: Part I. Quality Control,Comparisons and Variability

    Purpose: Optical coherence tomography (OCT) has been utilized to investigate papilledema in single site, mostly retrospective studies. We investigated whether spectral domain OCT (SD-OCT), which provides thickness and volume measurements of the optic nerve and retina, could reliably demonstrate structural changes due to papilledema in a prospective multi-site clinical trial setting. Methods: At entry, 126 subjects in the Idiopathic Intracranial Hypertension Treatment Trial (IIHTT) with mild visual field loss had optic disc and macula scans using the Cirrus SD-OCT. Images were analyzed using the proprietary commercial and custom 3-D segmentation algorithms to calculate retinal nerve fiber layer (RNFL), total retinal ...

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