1. Feasibility of ablative fractional laser-assisted drug delivery with optical coherence tomography

    Feasibility of ablative fractional laser-assisted drug delivery with optical coherence tomography

    Fractional resurfacing creates hundreds of microscopic wounds in the skin without injuring surrounding tissue. This technique allows rapid wound healing owing to small injury regions, and has been proven as an effective method for repairing photodamaged skin. Recently, ablative fractional laser (AFL) treatment has been demonstrated to facilitate topical drug delivery into skin. However, induced fractional photothermolysis depends on several parameters, such as incident angle, exposure energy, and spot size of the fractional laser. In this study, we used fractional CO 2 laser to induce microscopic ablation array on the nail for facilitating drug delivery through the nail. To ensure ...

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