1. Vessel Response After First- and Second-Generation Drug-Eluting Stent Detected by Optical Coherence Tomography – Pathological Background and Clinical Importance -

    Vessel Response After First- and Second-Generation Drug-Eluting Stent Detected by Optical Coherence Tomography – Pathological Background and Clinical Importance -

    Editorial. Although drug-eluting stents (DES) have dramatically decreased restenosis and target lesion revascularization rates, very late stent thrombosis has emerged as a new problem related to first-generation DES. Abnormal inflammatory vessel response to the polymer has been considered responsible for the development of stent thrombosis.1 Pathological examinations have revealed that in-stent neointima after implantation of a first-generation DES may contain inflammatory cells and fibrin. Recently, optical coherence tomography (OCT) has become widely available as a high resolution intracoronary imaging modality for detecting coronary plaque, providing the detailed morphological features related to unfavorable

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