1. In vivo functional microangiography by visible-light optical coherence tomography

    In vivo functional microangiography by visible-light optical coherence tomography

    Although hemoglobin oxygen saturation (sO 2 ) in the microvasculature is an essential physiological parameter of local tissue functions, non-invasive measurement of microvascular sO 2 is still challenging. Here, we demonstrated that visible-light optical coherence tomography (vis-OCT) can simultaneously provide three-dimensional anatomical tissue morphology, visualize microvasculature at the capillary level, and measure sO 2 from the microvasculature in vivo . We utilized speckle contrast caused by the moving blood cells to enhance microvascular imaging. We applied a series of short-time inverse Fourier transforms to obtain the spectroscopic profile of blood optical attenuation, from which we quantified sO 2 . We validated the sO ...

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