1. Ultrasensitive detection of 3D cerebral microvascular network dynamics in vivo

    Ultrasensitive detection of 3D cerebral microvascular network dynamics in vivo

    Despite widespread applications of multiphoton microscopy in microcirculation, its small field of view and inability to instantaneously quantify cerebral blood flow velocity (CBFv) in vascular networks limit its utility in investigating the heterogeneous responses to brain stimulations. Optical Doppler tomography (ODT) provides 3D images of CBFv networks, but it suffers poor sensitivity for measuring capillary flows. Here we report on a new method, contrast-enhanced ODT with Intralipid that significantly improves quantitative CBFv imaging of capillary networks by obviating the errors from long latency between flowing red blood cells (low hematocrit ~ 20% in capillaries). This enhanced sensitivity allowed us to measure ...

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