1. Age-related Differences in Longitudinal Structural Change by Spectral Domain Optical Coherence Tomography in Early Experimental Glaucoma

    Age-related Differences in Longitudinal Structural Change by Spectral Domain Optical Coherence Tomography in Early Experimental Glaucoma

    Purpose. To characterize age-related differences in the magnitude of Spectral Domain Optical Coherence Tomography (SDOCT) structural change in early experimental glaucoma (EG). Methods. Both eyes from 4 young (1.4 - 2.6 yrs) and 4 old (18.6 - 21.9 yrs) rhesus monkeys were imaged at least 3 times at baseline, and then every 2 weeks following laser-induced, chronic, unilateral IOP elevation until the onset of EG (Confocal Scanning Laser Tomographic surface change confirmed twice). Two to 20 weeks after EG onset, animals were sacrificed and optic nerve axon counts for all eyes were performed. Masked operators delineated retinal and ...

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