1. Optical coherence Doppler tomography for quantitative cerebral blood flow imaging

    Optical coherence Doppler tomography for quantitative cerebral blood flow imaging

    Optical coherence Doppler tomography (ODT) is a promising neurotechnique that permits 3D imaging of the cerebral blood flow (CBF) network; however, quantitative CBF velocity (CBFv) imaging remains challenging. Here we present a simple phase summation method to enhance slow capillary flow detection sensitivity without sacrificing dynamic range for fast flow and vessel tracking to improve angle correction for absolute CBFv quantification. Flow phantom validation indicated that the CBFv quantification accuracy increased from 15% to 91% and the coefficient of variation (CV) decreased 9.3-fold;in vivo mouse brain validation showed that CV decreased 4.4-/10.8- fold for venular ...

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