1. Spectral-domain optical coherence tomography features preceding new-onset neovascular membrane formation

    Spectral-domain optical coherence tomography features preceding new-onset neovascular membrane formation

    Objective To determine the frequency and characteristic spectral-domain optical coherence tomography (SD-OCT) features preceding new-onset choroidal neovascularization (CNV) in the fellow eye of neovascular age-related macular degeneration (AMD) with SD-OCT. Design A prospective, observational study. Participants Sixty-eight fellow eyes of patients with unilateral CNV. Methods SD-OCT was performed at baseline and then monthly. The main outcome measure is the description of retinal morphology 1 month before new onset of neovascularization. Results During the 48-month observation period, new-onset CNV was observed in 27 fellow eyes. Several morphologic features characterized SD-OCT images ≥1 months before new onset of CNV. These included new ...

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