1. Frequency-Domain Optical Coherence Tomographic Analysis of Plaque Microstructures at Non-culprit Narrowings in Patients Receiving Potent Statin Therapy

    Frequency-Domain Optical Coherence Tomographic Analysis of Plaque Microstructures at Non-culprit Narrowings in Patients Receiving Potent Statin Therapy

    Potent statin therapy has been demonstrated to reduce cardiovascular events. While statins have been considered to stabilize atherosclerotic plaque, this effect has not been well characterized in vivo. We investigated the relationship between potent statin therapy and plaque microstructures imaged by frequency-domain optical coherence tomography (FD-OCT). 290 non-culprit lipid plaques in 275 patients with stable coronary artery disease receiving atorvastatin or rosuvastatin were analyzed. Patients were stratified into no statin, low- and high-dose statin group. Plaques in the high-dose statin group demonstrated a smaller lipid arc (p=0.02) and a greater fibrous cap thickness (p=0.01). In patients ...

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