1. Evaluation of OCT for quantitative in-vivo measurements of changes in neural tissue scattering in longitudinal studies of retinal degeneration in mice

    Evaluation of OCT for quantitative in-vivo measurements of changes in neural tissue scattering in longitudinal studies of retinal degeneration in mice

    Optical coherence tomography is an imaging modality that is broadly used in ophthalmic diagnostics. The current generation of OCT systems enables reliable acquisition of volumetric scans containing information about the thicknesses of the various retinal layers. Thus, monitoring layer thickness changes is the main quantitative analysis performed by commercial instruments. In principle, measurements of the OCT signal intensity could also provide information on the health status of the retinal tissue. Unfortunately quantitative measurements and interpretation of scattering changes in retinal OCT is very limited due to variation in overall brightness of the OCT B-scans between imaging sessions. These changes might ...

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