1. Usefulness of optical coherence tomography to detect central serous chorioretinopathy in monkeys

    Usefulness of optical coherence tomography to detect central serous chorioretinopathy in monkeys

    Many systemic drugs can induce ocular toxicity and several ocular side-effects have been identified in clinical studies. However, it is difficult to detect ocular toxicity in preclinical studies because of the lack of appropriate evaluation methods. Optical coherence tomography (OCT) is useful because it can provide real-time images throughout a study period, whereas histopathology only provides images of sacrificed animals. Using OCT alongside histopathology, attempts were made to find effective approaches for screening of drug-induced ocular toxicity in monkeys. Such approaches could be used in preclinical studies prior to human trials. Six male cynomolgus monkeys ( Macaca fascicularis Raffles ) were orally ...

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