1. Nano-sensitive optical coherence tomography (nsOCT) for depth resolved characterization of 3D submicron structure

    Nano-sensitive optical coherence tomography (nsOCT) for depth resolved characterization of 3D submicron structure

    Nowadays optical coherence tomography (OCT) is a rapidly developing technique with various applications, including biomedical imaging and diagnosis. One of the main shortcomings of current OCT techniques is low resolution and sensitivity to structural changes (typically about 10 microns). The best ultra-high resolution OCT techniques demonstrate sensitivity to structural changes and depth resolution of about 1 micron. Since many applications of interest (such as cancer) depend on structural changes at the nanoscale, OCT would definitely benefit from improved structural resolution and sensitivity. A new spectral encoding of spatial frequency (SESF) approach for quantitative characterization of the structure with nanoscale sensitivity ...

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