1. Retinal Blood Flow and Nerve Fiber Layer Measurements in Early-Stage Open-Angle Glaucoma

    Purpose: To evaluate the relationship between retinal circulatory abnormalities and retinal nerve fiber layer (RNFL) thinning in early-stage open-angle glaucoma (OAG) to help elucidate the mechanisms underlying the development of glaucomatous optic neuropathy. Design: Prospective cross-sectional.Methods: Twelve patients with early OAG and a known maximum untreated intraocular pressure less than 22 mm Hg (age, 61.4 ± 9.7 years; Humphrey visual field mean deviation −2.7 ± 2.1) and eight age-matched healthy control subjects (age, 58.5 ± 8.3 years) were included in the study. Blood column diameter, centerline blood speed, and retinal blood flow were measured in the ...
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