1. High-resolution spectral domain-optical coherence tomography in multiple sclerosis, Part II – the total macular volume. The first follow-up study over 2 years

    High-resolution spectral domain-optical coherence tomography in multiple sclerosis, Part II – the total macular volume. The first follow-up study over 2 years

    Background: Recent studies investigating the use of optical coherence tomography (OCT) in multiple sclerosis (MS) patients have resulted in wide-ranging and often contradictory outcomes. This is mainly due to the complex etiology and heterogeneity of MS, physiological variations in the retinal nerve fiber layer (RNFL) and/or total macular volume (TMV), and limitations in methodology. It remains to be discovered whether any retinal changes in MS develop continuously or in a stepwise fashion, and whether these changes occur in all or a subset of patients. High-resolution spectral domain-OCT devices (SD-OCT) would be required to detect subtle retinal changes and longitudinal ...

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