1. Optical Coherence Tomography as a Novel Tool for In-Line Monitoring of a Pharmaceutical Film-Coating Process

    Optical Coherence Tomography as a Novel Tool for In-Line Monitoring of a Pharmaceutical Film-Coating Process

    Optical coherence tomography (OCT) is a contact-free non-destructive high-resolution imaging technique based on low-coherence interferometry. This study investigates the application of spectral-domain OCT as an in-line quality control tool for monitoring pharmaceutical film-coated tablets. OCT images of several commercially-available film-coated tablets of different shapes, formulations and coating thicknesses were captured off-line using two OCT systems with centre wavelengths of 830 nm and 1325 nm. Based on the off-line image evaluation, another OCT system operating at a shorter wavelength was selected to study the feasibility of OCT as an in-line monitoring method. Since in spectral-domain OCT motion artefacts can occur as ...

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