1. Noninvasive Imaging of Retinal Morphology and Microvasculature in Obese Mice using Optical Coherence Tomography and Optical Microangiography

    Noninvasive Imaging of Retinal Morphology and Microvasculature in Obese Mice using Optical Coherence Tomography and Optical Microangiography

    Purpose:To evaluate early diabetes-induced changes in retinal thickness and microvasculature in a type II diabetic mouse model using OCT/OMAG. Methods:22 week old obese BTBR mice (OB, n=10) and wild type control mice (WT, n=10) were imaged. Three-dimensional data were captured with OCT using an ultrahigh sensitive OMAG scanning protocol for 3D angiography of the retina and dense A-scan protocol for measurement of the total retinal blood flow (RBF) rate. The thickness of the nerve fiber layer (NFL) and NFL to inner plexiform layer (IPL) were measured and compared between OB and WT mice. The linear ...

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