Contrasting properties of gold nanoparticles for optical coherence tomography: phantom, in vivo studies and Monte Carlo simulation

Entities Mentioned

• Russian Academy of Sciences
• University of Oulu
• Nizhny Novgorod State Medical Academy
• Vladislav A. Kamensky
• Elena V. Zagaynova
• Mikhail Y. Kirillin
• Pavel D. Agrba

1. Abstract. The possibility of using silica–gold nanoshells with 150 nm silica core size and 25 nm thick gold shell as contrasting agents for optical coherence tomography (OCT) is analyzed. Experiments on agar biotissue phantoms showed that the penetration of nanoshells into the phantoms increases the intensity of the optical coherence tomography (OCT) signal and the brightness of the corresponding areas of the OCT image. In vivo experiments on rabbit skin demonstrated that the application of nanoshells onto the skin provides significant contrasting of the borders between the areas containing nanoshells and those without. This effect of nanoshells on skin in ... (Read Full Article)

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