1. Feature Of The Week 11/24/13 : Miniature OCT/IVUS probe for automatically co-registered three-dimensional intracoronary imaging with real-time display

    Feature Of The Week 11/24/13 : Miniature OCT/IVUS probe for automatically co-registered three-dimensional intracoronary imaging with real-time display

    Combined use of intravascular ultrasound (IVUS) and optical coherence tomography (OCT) holds the potential of combining the strengths of both imaging modalities and improving the diagnostic accuracy of atherosclerotic plaque vulnerability. In this manuscript, we reported a co-registered intracoronary OCT-IVUS system and catheter with real-time imaging and polar-coordinate displaying capability, well-suited for clinical utilization in guiding interventional cardiologists. With an eventual goal of clinical use in humans, this novel catheter design and modified software are poised to strengthen the ability to diagnose vulnerable plaques in patients in real-time. We upgraded our old designs in the following aspects. 1) This novel probe design enables automatically co-registered OCT-IVUS imaging, i.e., OCT and IVUS are imaging at the same region of interest simultaneously. 2) This probe design has shorter rigid-part for safer catheterization procedures; the novel probe has an identical rigid-part size with the clinically-used IVUS or OCT probe, has a clinically acceptable outer diameter (OD), and does not sacrifice image quality. 3) Modified system has real-time imaging and polar-coordinate display capability. We report the first demonstration of real-time 3D OCT-IVUS imaging and display in a FH swine coronary artery, a common animal model for atherosclerosis study. The 3D video shows the automatically co-registered capability of this OCT-IVUS imaging probe. In human cadaver experiments, three major types of plaques’ morphologic characteristics were clearly shown.

    In this manuscript, most technical problems of the OCT-IVUS system and catheter have been solved. Our work promises the safe clinical application of this technique in the near future.

    For more information see recent Article. Courtesy of Jiawen Li and Zhongping Chen from University of California at Irvine.  This work was a collaboration between Dr. Zhongping Chen's and Dr. Qifa Zhou's Groups, supported by a NIH R01 Grant.

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