1. Spectral Domain Optical Coherence Tomography for Quantitative Evaluation of Drusen and Associated Structural Changes in Non-Neovascular Age Related Macular Degeneration

    Background/Aims: To demonstrate how spectral domain optical coherence tomography (SDOCT) can better evaluate drusen and associated anatomic changes in eyes with non-neovascular age related macular degeneration (AMD) compared to time domain optical coherence tomography (TDOCT). Methods: Images were obtained from 3 eyes of 3 patients with AMD using an experimental SDOCT system. Both a Titanium-sapphire (Ti:Sapphire) laser and a superluminescent diode (SLD) was used as a broadband light source to achieve cross-sectional images of the retina. Qualitative and quantitative analysis was done of structural changes associated with non-neovascular AMD. An automated algorithm was developed to analyze drusen size ...

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