1. Optical Coherence Tomography in the Diagnosis of Optic Pathway Gliomas

    Optical Coherence Tomography in the Diagnosis of Optic Pathway Gliomas

    Purpose: To compare visual function assessment, optic disc evaluation by indirect ophthalmoscopy and retinal nerve fibres layer analysis by optical coherence tomography (OCT) for the screening of optic pathway gliomas in paediatric patients (2-15 years) affected by neurofibromatosis type-1. Methods: Fifty-seven consecutive patients affected by neurofibromatosis type-1 with recent (<6 moths) orbital/brain MRI were included. Patients underwent visual function assessment (Hyvarinen symbols chart and/or Snellen charts) and optic disc evaluation by indirect ophthalmoscopy by experienced, masked paediatric ophthalmologists. Spectral domain-OCT was performed to assess retinal nerve fibres layer. Results: Fifteen out of fifty-seven enrolled patients were affected by ...

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