1. Evaluation of retinal nerve fiber layer and ganglion cell layer thickness in Alzheimer's disease using spectral-domain optical coherence tomography

    Evaluation of retinal nerve fiber layer and ganglion cell layer thickness in Alzheimer's disease using spectral-domain optical coherence tomography

    Purpose: To evaluate differences between the retinal nerve fiber layer (RNFL) thickness and RNFL + ganglion cell layer (GCL) thickness in patients affected by Alzheimer's disease (AD) and healthy patients using spectral-domain optical coherence tomography (SD-OCT). Methods: This was a case-control prospective study. Twenty-one AD patients and 21 healthy subjects underwent neurological examination, clock drawing test (CDT), mini mental state examination (MMSE) and comprehensive ophthalmic evaluation with visual acuity. SD-OCT examination was performed using Spectralis (Heidelberg Engineering, Heidelberg, Germany), and RTVue-100 (Optovue Inc., Freemont, CA, USA). A RNFL thickness map was obtained using the Spectralis volume protocol with 19 lines ...

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