1. Relationship between Retinal Nerve Fiber Layer Measurement and Signal Strength in Optical Coherence Tomography

    Purpose To examine the relationship between signal strength and retinal nerve fiber layer (RNFL) thickness measured by optical coherence tomography (OCT). Design Observational cross-sectional study. Participants Forty normal subjects were recruited. Methods Retinal nerve fiber layer (RNFL) thickness was measured by Stratus OCT (Carl Zeiss Meditec, Dublin, CA). In each eye, the focusing knob was adjusted to obtain 6 images with different signal strengths ranging from 5 to 10. The relationships between signal strength and RNFL thickness were examined using the Spearman correlation coefficient. The differences of RNFL thicknesses were compared with repeated-measures analysis of variance. Main Outcome Measures Retinal ...
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