1. Reproducibility of Diabetic Macular Edema estimates from SD-OCT is affected by the choice of image analysis algorithm

    Reproducibility of Diabetic Macular Edema estimates from SD-OCT is affected by the choice of image analysis algorithm

    Purpose: To evaluate the inter-session repeatability of retinal thickness measurements in patients with diabetic macular edema (DME) using the Heidelberg Spectralis OCT algorithm and a publicly available, 3D graph search based multilayer OCT segmentation algorithm, the Iowa Reference Algorithm. Methods: 30 eyes from 21 patients diagnosed with clinically significant DME were included and underwent consecutive, registered macula-centered spectral domain optical coherence scans (Heidelberg Spectralis). The OCT scans were segmented into separate surfaces and the average thickness between internal limiting membrane and outer retinal pigment epithelium complex surfaces was determined using the Iowa Reference Algorithm. Variability between paired scans was analyzed ...

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