1. Alterations in Pulse Wave Propagation Reflect the Degree of Outflow Tract Banding in HH18 Chicken Embryos

    Alterations in Pulse Wave Propagation Reflect the Degree of Outflow Tract Banding in HH18 Chicken Embryos

    Hemodynamic conditions play a critical role in embryonic cardiovascular development, and altered blood flow leads to congenital heart defects. Chicken embryos are frequently used as models of cardiac development, with abnormal blood flow achieved through surgical interventions such as outflow tract (OFT) banding, in which a suture is tightened around the heart OFT to restrict blood flow. Banding in embryos increases blood pressure and alters blood flow dynamics, leading to cardiac malformations similar to those seen in human congenital heart disease. In studying these hemodynamic changes, synchronization of data to the cardiac cycle is challenging, and alterations in the timing ...

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